Dual energy subtraction for contrast enhanced digital breast tomosynthesis

The fast ray-tracing exploreddual-energy combinations to identify which yields optimum mass SdNR. The issue of radiation dose also needs to be considered in terms of safety for women being screened".

The mass SdNR was examined as a basis to optimize dual-energy contrast-enhanced tomosynthesis in both the tomosynthesis projections and reconstructed slices. For women with dense breasts given the choice of US or tomosynthesis, US shows more cancers. The objectives of this study were to assess the clinical feasibility of CE-DBT as an adjunct to digital mammography, and to correlate lesion enhancement characteristics and morphology obtained with CE-DBT to digital mammography, ultrasound, and magnetic resonance MR.

These researchers reported a high-resolution, low-dose phase contrast X-ray tomographic method for 3D diagnosis of human breast cancers. Today, contrast-enhanced MRI CE-MRIwhich uses a gadolinium chelate as a vascular contrast agent, is the standard for vascular imaging of breast cancers [ 2 — 7 ].

Initial Clinical Experience with Contrast-Enhanced Digital Breast Tomosynthesis

A total of women underwent 2D DM including supplementary cone-down and magnification views and breast ultrasonography if indicated, as well as DBT.

CAD assists the radiologist by identifying areas warranting further review. After ethics approval, CESM and MRI examinations were performed in patients who had suspicious lesions described in conventional mammography. Between the pre- and post-contrast DBT image sets, a single bolus of iodinated contrast agent 1.

The authors concluded that addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate.

The log of this signal is ln. On the basis of the results from ASTOUND, tomosynthesis still misses a substantial number of invasive cancers in women with dense breasts: They stated that although evidence of improved screening benefit is currently lacking for density-tailored screening, what makes the issue of DBT screening for dense breasts immediately relevant in breast imaging and screening practice is the implementation of density-specific legislation in some settings, plus the reality of using DBT alone for primary screening.

Main outcome measures included cancer detection rate yieldsensitivity, specificity, positive-predictive value PPV of biopsies performed and interval cancer rate. The weighting factor was optimized to minimize anatomical noise, while the dose distribution was chosen to minimize quantum noise.

A framework for system characterization was set up that included quantum and anatomical noise and a theoretical model of the system was benchmarked to phantom measurements.

A phantom model with wells of iodinated contrast material 3 mg of iodine per milliliter 1, 2, 5, 10, and 15 mm in diameter was assessed.

Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study

This subtracted tomosynthesis image set had the same dimensions as the pre- and post-contrast image sets. A data set of 2-view DBT of 72 breasts containing micro-calcification clusters was collected from 72 subjects who were scheduled to undergo breast biopsy.

All visible lesions were evaluated independently by 2 experienced radiologists using BI-RADS classifications scale 1 to 5. Spangler and colleagues compared the ability of digital breast tomosynthesis and full field digital mammography FFDM to detect and characterize calcifications. Data on women under age 50 are less clear.

Finally, no multi-centric or multi-focal BCs were included in the study. Two reviewers selected and evaluated the articles. The authors concluded that no statistically significant differences were found between soft-copy digital and screen-film mammography for Fischer, Fuji, and GE digital mammography equipment.

Table 1 summarizes the multimodality imaging results for the index lesion of each patient. Although the extent to which this new software technology has been implemented in mammography screening centers is not precisely known, it is currently thought to be low.

Three breast imagers correlated the tomographic images with the other imaging modalities. Analyses of data from all 43 facilities showed that the use of CAD was associated with significantly lower overall accuracy than was non-use area under the ROC curve, 0.

Poller et al stated that annual ultrasound screening may detect small, node-negative breast cancers that are not seen on mammography; and magnetic resonance imaging MRI may reveal additional breast cancers missed by both mammography and ultrasound screening.

Theoretical and experimental SDNR values differ, on average, by 1. Sensitivity for MRI and mammography plus ultrasound was 1.


Mean glandular doses were restricted to ensure clinical relevance. Purpose: Previously, the authors developed a dual-energy (DE) acquisition technique for a photon-counting digital breast tomosynthesis (DBT) imaging system. Low-energy (LE) and high-energy (HE) images are acquired in a single scan by covering alternate slits of a multislit prepatient collimator with.

A technique for demonstrating breast cancers, dual-energy contrast agent–enhanced digital subtraction mammography, was performed in 26 subjects with mammographic or clinical findings that warranted biopsy. Contrast-Enhanced Digital Breast Tomosynthesis Dual Energy Subtraction Temporal Subtraction vascular contrast agent Download to read the.

Dual-energy contrast-enhanced breast tomosynthesis is a promising technique to obtain three-dimensional functional information from the breast with high resolution and speed.

To optimize this new method, this study searched for the beam quality that maximized image quality in terms of mass detection performance.

Contrast-enhanced digital breast tomosynthesis (CE-DBT) is a novel modality for imaging breast lesion morphology and vascularity. The purpose of this study is to assess the feasibility of dual-energy subtraction as a technique for CE-DBT (a temporal subtraction CE-DBT technique has been described previously).

As CE-DBT evolves, exploration. Dual-energy contrast-enhanced breast tomosynthesis is a promising technique to obtain three-dimensional functional information from the breast with high resolution and speed.

Dual energy subtraction for contrast enhanced digital breast tomosynthesis
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